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Фото Robust Clustering for Gene Expression Data Study in Bioinformatics cervical cancer in amhara region in ethiopia

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Robust Clustering for Gene Expression Data Study in Bioinformatics

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Фото Auto-immunity in Colorectal Cancer: Anti-p53 and anti-hTERT antibody cervical cancer in amhara region in ethiopia

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Auto-immunity in Colorectal Cancer: Anti-p53 and anti-hTERT antibody

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Фото Opportunities and Challenges of Banking Industry cervical cancer in amhara region in ethiopia

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Opportunities and Challenges of Banking Industry

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Фото Malaria Study in Tribal Areas of Betul-Chhindwara Region M.P.(India) cervical cancer in amhara region in ethiopia

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Malaria Study in Tribal Areas of Betul-Chhindwara Region M.P.(India)

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Фото An endogenous rural developing plan of a mountainous region in Cyprus cervical cancer in amhara region in ethiopia

An endogenous rural...

An endogenous rural developing plan of a mountainous region in Cyprus

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Фото Rural Food Poverty In Jikawo, Gambella cervical cancer in amhara region in ethiopia

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Rural Food Poverty In Jikawo, Gambella

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Фото Management of Clinical Depression and Anxiety cervical cancer in amhara region in ethiopia

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Management of Clinical Depression and Anxiety

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Фото Radiotherapy for Head and Neck Cancer cervical cancer in amhara region in ethiopia

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Radiotherapy for Head and Neck Cancer

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Фото Recapitulation Of Water And Wetland Resources Of Ethiopia cervical cancer in amhara region in ethiopia

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Recapitulation Of Water And Wetland Resources Of Ethiopia

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Фото Indigenous Rangeland and Water Resources Management Practices cervical cancer in amhara region in ethiopia

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Indigenous Rangeland and Water Resources Management Practices

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Фото Depression, Anxiety and Stress in Young Adult Breast Cancer Women cervical cancer in amhara region in ethiopia

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Depression, Anxiety and Stress in Young Adult Breast Cancer Women

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Фото Landuse/Landcover change dynamics due to Resettlement cervical cancer in amhara region in ethiopia

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Landuse/Landcover change dynamics due to Resettlement

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Фото Effects of microtubule-interfering agents on AhR signalling cervical cancer in amhara region in ethiopia

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Effects of microtubule-interfering agents on AhR signalling

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Для информации:

Carcinogenesis is a multi-aetiological process involving alterations of key biomolecular markers. These are recognised by the humoral system and known as Tumour Associated Antigens (TAA) against which the humoral system mounts an auto-antibody response. Cancer cells are subject to two key mortality barriers (M1 & M2) as described in the “2-hit” hypothesis. These are overcome by p53 dysfunction in M1 and hTERT re-expression in M2. Auto-antibodies are produced in response to these two TAA. This book investigates the significance of the anti-p53 and anti-hTERT auto-antibody response. The initial literature review of anti-p53 auto-antibody in all cancers (1979-2010) forms the largest body of evidence of correlation between anti-p53 auto-antibody and p53 mutation to date. This is followed by results of our anti-p53 study and evaluation of all published studies of anti-p53 in colorectal cancer. Anti-hTERT has only been reported once, using molecular recombination to develop the hTERT antigen. The latter section of this book aims to develop a less restrictive technology for mass detection of anti-hTERT. This humoral response could enable earlier identification of CRC and impact prognosis.