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cervical cancer in amhara region in ethiopia

Фото Regional Integration Dynamics in Central Africa: an appraisal of ECCAS cervical cancer in amhara region in ethiopia

Regional Integration...

Regional Integration Dynamics in Central Africa: an appraisal of ECCAS

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Фото DACS DB: Disease associated cytokine SNPs database cervical cancer in amhara region in ethiopia

DACS DB: Disease ass...

DACS DB: Disease associated cytokine SNPs database

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Фото Universities as Growth Poles cervical cancer in amhara region in ethiopia

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Universities as Growth Poles

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Фото The Paradox of Circulation Increase and Reduced ROI in Newspapers cervical cancer in amhara region in ethiopia

The Paradox of Circu...

The Paradox of Circulation Increase and Reduced ROI in Newspapers

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Фото Coming to the Surface cervical cancer in amhara region in ethiopia

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Coming to the Surface

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Фото Climate Change Induced Agricultural Scenarios in Bangladesh cervical cancer in amhara region in ethiopia

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Climate Change Induced Agricultural Scenarios in Bangladesh

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Фото Gene therapy for breast cancer treatment cervical cancer in amhara region in ethiopia

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Gene therapy for breast cancer treatment

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Фото Mobile phone causes cancer cervical cancer in amhara region in ethiopia

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Mobile phone causes cancer

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Фото Land reform process in Namibia cervical cancer in amhara region in ethiopia

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Land reform process in Namibia

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Фото Assessment of In-School Conflicts and their Resolutions cervical cancer in amhara region in ethiopia

Assessment of In-Sch...

Assessment of In-School Conflicts and their Resolutions

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Фото ENHANCING RESEARCH-EXTENSION-FARMERS LINKAGE IN ETHIOPIA cervical cancer in amhara region in ethiopia

ENHANCING RESEARCH-E...

ENHANCING RESEARCH-EXTENSION-FARMERS LINKAGE IN ETHIOPIA

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Фото Mastitis in East Shoa, Ethiopia cervical cancer in amhara region in ethiopia

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Mastitis in East Shoa, Ethiopia

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Фото Causes and Characteristics of Brain Drain in Ethiopia cervical cancer in amhara region in ethiopia

Causes and Character...

Causes and Characteristics of Brain Drain in Ethiopia

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Фото Vaccination coverage and influential factors in Ethiopia cervical cancer in amhara region in ethiopia

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Vaccination coverage and influential factors in Ethiopia

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Фото Trafficking Of Women In Ethiopia cervical cancer in amhara region in ethiopia

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Trafficking Of Women In Ethiopia

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Фото Population Change and Development Efforts in Ethiopia cervical cancer in amhara region in ethiopia

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Population Change and Development Efforts in Ethiopia

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Для информации:

Breast cancer is the most common type of neoplasia in women. Most of hereditary cases are associated with mutations of breast cancer-associated genes (BRCA). Preventive mastectomy and chemoprevention are the only approaches available so far to prevent the development of neoplasia in patients with specific genetic background. However, side effects and invasiveness of these procedures make necessary the development of alternative strategies. This book describes a novel approach to prevent breast cancer based on the restoration of BRCA1 functional gene into target cells using an engineered virus. In fact viruses have developed an efficient mechanism to deliver their genetic material into target cells; virus-derived vectors take advantages of this ability to vehiculate transgenes cells. To this aim a lentiviral vector expressing BRCA1 gene was produced. Restoration of gene function was validated in tumor and primary cells derived from patient encoding an inactive form of BRCA1, that, following gene delivery, restored the ability to repair DNA damages upon exposition to ionizing radiations These results pave the way to develop novel preventative approaches against human breast cancer.