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cervical cancer in amhara region in ethiopia

Фото Application of GIS in Fisheries Sector of Greater Mumbai Region cervical cancer in amhara region in ethiopia

Application of GIS i...

Application of GIS in Fisheries Sector of Greater Mumbai Region

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Фото Climate Studies in Tropical Region cervical cancer in amhara region in ethiopia

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Climate Studies in Tropical Region

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Фото The Deportation Disaster cervical cancer in amhara region in ethiopia

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The Deportation Disaster

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Фото Justiciability of Socio-Economic Rights in Ethiopia cervical cancer in amhara region in ethiopia

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Justiciability of Socio-Economic Rights in Ethiopia

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Фото International Protection of Traditional Medical knowledge cervical cancer in amhara region in ethiopia

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International Protection of Traditional Medical knowledge

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Фото The Rights of the Girl-child in Ethiopia: Challenges and Prospects cervical cancer in amhara region in ethiopia

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The Rights of the Girl-child in Ethiopia: Challenges and Prospects

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Фото Diversity Analysis of Taro(Collocasia esculenta (L.)Schott)in Ethiopia cervical cancer in amhara region in ethiopia

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Diversity Analysis of Taro(Collocasia esculenta (L.)Schott)in Ethiopia

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Фото Child Malnutrition in Ethiopia cervical cancer in amhara region in ethiopia

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Child Malnutrition in Ethiopia

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Фото PAP,TPSA & FPSA as Markers of Prostate cancer in Sudanese patients cervical cancer in amhara region in ethiopia

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PAP,TPSA & FPSA as Markers of Prostate cancer in Sudanese patients

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Фото Methylation of APC tumor suppressor gene in bladder cancer cervical cancer in amhara region in ethiopia

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Methylation of APC tumor suppressor gene in bladder cancer

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Фото Angiogenesis and lymphangiogenesis in ovarian cancer cervical cancer in amhara region in ethiopia

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Angiogenesis and lymphangiogenesis in ovarian cancer

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Фото Novel Steroidal Breast Cancer Drugs cervical cancer in amhara region in ethiopia

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Novel Steroidal Breast Cancer Drugs

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Фото Economic Analysis of Sustainable Farm Income through Farming Systems cervical cancer in amhara region in ethiopia

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Economic Analysis of Sustainable Farm Income through Farming Systems

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Фото Economic Valuation of land use options in Ethiopia cervical cancer in amhara region in ethiopia

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Economic Valuation of land use options in Ethiopia

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Фото Factors Determining the Effectiveness of INGOS in Ethiopia cervical cancer in amhara region in ethiopia

Factors Determining...

Factors Determining the Effectiveness of INGOS in Ethiopia

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Фото Technical Efficiency of Coffee producers in Ethiopia cervical cancer in amhara region in ethiopia

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Technical Efficiency of Coffee producers in Ethiopia

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Для информации:

Bladder cancer is a major health problem in Egypt which constitutes 30% of all cancers. Cytology could serve as an excellent test for screening but it is of lower sensitivity. Early diagnosis is critical for maximizing the cure rate of bladder cancer , so many urine-based tumor markers have been developed for use in detecting and monitoring bladder cancers. Hypermethylation of CpG islands in the promoter regions of APC tumor suppressor gene is a major event in the origin of many cancers. In the present study detection of methylated APC gene was done in the urine of 183 subjects including normal, benign and malignant cases using MS-PCR technique. Results revealed marked urinary APC promoter hypermethylation in malignant group as compared to benign and normal groups. The sensitivity of detection of APC promoter hypermethylation was (57%) and the specificity was (98%), while the sensitivity of urine cytology was (44%).Combined use of detection of urinary APC promoter hypermethylation with urine cytology increased the sensitivity of cytology from 44% to 74%. So, detection of urinary APC promoter hypermethylation appears to be a promising marker for detecting new onset of bladder cancer.