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cervical cancer in amhara region in ethiopia

Фото Statistical Suit Of Prevalence Of Colorectal Cancer In Pakistan cervical cancer in amhara region in ethiopia

Statistical Suit Of...

Statistical Suit Of Prevalence Of Colorectal Cancer In Pakistan

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Фото Challenges and opportunities of irrigated agriculture cervical cancer in amhara region in ethiopia

Challenges and oppor...

Challenges and opportunities of irrigated agriculture

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Фото Poverty and Livelihood Strategeies of Househilds in Urban Ethiopia cervical cancer in amhara region in ethiopia

Poverty and Liveliho...

Poverty and Livelihood Strategeies of Househilds in Urban Ethiopia

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Фото The Nexus Between Public Spending and Economic Growth in Ethiopia cervical cancer in amhara region in ethiopia

The Nexus Between Pu...

The Nexus Between Public Spending and Economic Growth in Ethiopia

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Фото Inflammation and Cancer cervical cancer in amhara region in ethiopia

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Inflammation and Cancer

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Фото Use of Nano carriers in cancer therapy imaging and diagnosis cervical cancer in amhara region in ethiopia

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Use of Nano carriers in cancer therapy imaging and diagnosis

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Фото Dairy Cattle Productivity in Mizan – Aman District (SW-Ethiopia) cervical cancer in amhara region in ethiopia

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Dairy Cattle Productivity in Mizan – Aman District (SW-Ethiopia)

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Фото Impact of public Sectoral Expenditure on Economic Growth in Ethiopia cervical cancer in amhara region in ethiopia

Impact of public Sec...

Impact of public Sectoral Expenditure on Economic Growth in Ethiopia

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Фото Democratic Decentralization and its Implication on Service Delivery cervical cancer in amhara region in ethiopia

Democratic Decentral...

Democratic Decentralization and its Implication on Service Delivery

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Фото Influence of Filter Press Mud on Soil Physicochemical Properties cervical cancer in amhara region in ethiopia

Influence of Filter...

Influence of Filter Press Mud on Soil Physicochemical Properties

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Фото Modeling Floriculture Effluents on Soil Quality in Central Ethiopia cervical cancer in amhara region in ethiopia

Modeling Floricultur...

Modeling Floriculture Effluents on Soil Quality in Central Ethiopia

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Фото Oxidative phosphorylation in different diseases of gastric mucosa cervical cancer in amhara region in ethiopia

Oxidative phosphoryl...

Oxidative phosphorylation in different diseases of gastric mucosa

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Фото PLGA-BASED NANOPARTICLES IN CANCER IMMUNOTHERAPY AND IMMUNOMONITORING cervical cancer in amhara region in ethiopia

PLGA-BASED NANOPARTI...

PLGA-BASED NANOPARTICLES IN CANCER IMMUNOTHERAPY AND IMMUNOMONITORING

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Фото Land Tenure and Urbanization in Qajjima, Ethiopia (1880s to 1991) cervical cancer in amhara region in ethiopia

Land Tenure and Urba...

Land Tenure and Urbanization in Qajjima, Ethiopia (1880s to 1991)

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Фото Development Communication Enhancing Agroforestry in Ethiopia cervical cancer in amhara region in ethiopia

Development Communic...

Development Communication Enhancing Agroforestry in Ethiopia

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Фото Dimensions and Determinants of Urban Poverty in Dire Dawa, Ethiopia cervical cancer in amhara region in ethiopia

Dimensions and Deter...

Dimensions and Determinants of Urban Poverty in Dire Dawa, Ethiopia

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Для информации:

Survival rates of gastric cancer (GC) have been low, due to the fact that its diagnosis is often late and made in the advanced stage. The knowledge about the precursor lesions in development of gastric cancer could contribute to cancer diagnosis at an early stage. The biological development of GC in the gastric mucosa (GM) is characterized by the sequence: chronic inflammation-atrophic gastritis (AG)-dysplasia-GC. We aimed to investigate the function of oxidative phosphorylation (OXPHOS) in the GM cells in case of chronic gastritis, AG and GC and to find alterations, pointing to early pre-cancerous changes. Additionally, the energy transfer systems consist of adenylate kinase (AK) and creatine kinase (CK) intracellular and mitochondrial isoforms in case of chronic gastritis were studied. The results showed that: 1. In the human antrum and corpus GM exists AK and CK systems that are functionally coupled to OXPHOS. 2. In the atrophic corpus GM and in the GC cells oxidative capaciry is reduced and remodelling of the OXPHOS occurs, manifesting as deficiency of the complex I and improved function of the complex II. These changes may have a role in the development of gastric cancer.