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cervical cancer in amhara region in ethiopia

Фото Institutional Capacity to Administer and Enforce IP Rights in Ethiopia cervical cancer in amhara region in ethiopia

Institutional Capaci...

Institutional Capacity to Administer and Enforce IP Rights in Ethiopia

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Фото More Secured, More Conserved? cervical cancer in amhara region in ethiopia

More Secured, More C...

More Secured, More Conserved?

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Фото Inter-ethnic Conflict Transformation in Ethiopia cervical cancer in amhara region in ethiopia

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Inter-ethnic Conflict Transformation in Ethiopia

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Фото Patterns of Lung Cancer in North-Western Pakistan cervical cancer in amhara region in ethiopia

Patterns of Lung Can...

Patterns of Lung Cancer in North-Western Pakistan

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Фото Public Final Consumption, Investment and Economic Growth in Ethiopia cervical cancer in amhara region in ethiopia

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Public Final Consumption, Investment and Economic Growth in Ethiopia

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Фото Urine protein and immunity in breast cancer patients cervical cancer in amhara region in ethiopia

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Urine protein and immunity in breast cancer patients

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Фото Involvement of Reactive Nitrogen Species and NF-?B in colon cancer cervical cancer in amhara region in ethiopia

Involvement of React...

Involvement of Reactive Nitrogen Species and NF-?B in colon cancer

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Фото Rethinking Ethiopia''s Choice of Working Language cervical cancer in amhara region in ethiopia

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Rethinking Ethiopia''s Choice of Working Language

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Фото Predictors in rectal cancer patients cervical cancer in amhara region in ethiopia

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Predictors in rectal cancer patients

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Фото Sustainability Levels in the Niger Delta Region of Nigeria cervical cancer in amhara region in ethiopia

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Sustainability Levels in the Niger Delta Region of Nigeria

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Фото Agricultural Biotechnology for Food Security cervical cancer in amhara region in ethiopia

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Agricultural Biotechnology for Food Security

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Фото Cancer: Diagnosis & Future Chemoprotective Agents cervical cancer in amhara region in ethiopia

Cancer: Diagnosis &...

Cancer: Diagnosis & Future Chemoprotective Agents

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Фото The role of Cobble Stone Project in Urban Infrastructure Development cervical cancer in amhara region in ethiopia

The role of Cobble S...

The role of Cobble Stone Project in Urban Infrastructure Development

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Фото Radiobiology in Prostate Cancer Treatment cervical cancer in amhara region in ethiopia

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Radiobiology in Prostate Cancer Treatment

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Фото Cancer and Nanodelivery cervical cancer in amhara region in ethiopia

Cancer and Nanodeliv...

Cancer and Nanodelivery

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Для информации:

The reactive nitrogen species peroxynitrite is a product of the reaction of nitric oxide with superoxide. This powerful oxidant has been proposed to contribute to the pathology of a large variety of diseases associated with increased inflammation and cancer development by its ability to oxidize and nitrate a variety of macromolecules. The transcription factor NF-?B is a predominant player in inflammatory and carcinogenic processes and has been found to play a major role in the transition from chronic inflammation to cancer initiation. In this study the molecular mechanisms by which NF-?B is activated under nitrative stress in a human colon cancer cell line and in colitis and human colon cancer sections of patients were investigated. The in vitro studies showed a dynamic, kinetic, and intensity activation of NF-?B caused by peroxynitrite, lead to an aberrant and belated pathway compared to the canonical activation by TNF-?. It occurred in a simultaneous dual mechanism: IKK dependent, by which p38 MAPK was found to be involved, and IKK independent. The clinical studies supported these findings with high activation of NF-kB and its target genes in colitis and colon cancer sections.